| Date | Location | Result | |
| Nov 06, 2010 | Owensboro, KY | Kentucky Wesleyan 28, Notre Dame College 14 | Box score |
| Oct 30, 2010 | Owensboro, KY | Kentucky Wesleyan 40, Miles 28 | Box score |
| Oct 23, 2010 | Owensboro, KY | Saint Joseph's 43, Kentucky Wesleyan 35 | Box score |
| Oct 16, 2010 | Rolla, MO | Missouri S&T 38, Kentucky Wesleyan 35 | Box score |
| Oct 09, 2010 | Urbana, OH | Urbana 39, Kentucky Wesleyan 25 | Box score |
| Oct 02, 2010 | Mobile, AL | South Alabama 52, Kentucky Wesleyan 3 | Box score |
| Sep 25, 2010 | Owensboro, KY | Kentucky Wesleyan 49, Alma 28 | Box score |
| Sep 18, 2010 | Wilberforce, OH | Kentucky Wesleyan 38, Central State 33 | Box score |
| Sep 11, 2010 | Owensboro, KY | Kentucky Wesleyan 34, Pikeville 28 | Box score |
| Sep 02, 2010 | Owensboro, KY | Indianapolis 38, Kentucky Wesleyan 10 | Box score |